The Test at the Principality Stadium, the fourth of the Springboks’ tour to the northern hemisphere, kicks off at 17:20.
Duane Vermeulen, Pieter-Steph du Toit and Siya Kolisi will yet again form the loose trio, Franco Mostert and RG Snyman the lock combination while Frans Malherbe, Malcolm Marx and Steven Kitshoff will pack down in the front row.
Jesse Kriel will play in his 40th Test match for the Springboks and he lines up next to Damian de Allende in the midfield. Handré Pollard and Embrose Papier are the halfbacks and the back three consists of Willie le Roux and speedsters Sbu Nkosi and Aphiwe Dyantyi.
Following an agonising one-point loss to England at Twickenham at the start of the tour, the Springboks have subsequently gained hard-fought victories over France in Paris and Scotland.
Success over Wales at the Principality Stadium will mean the South Africans can finish the traditional end of year tour with three wins from four.
South Africa team to face Wales
15. Willie le Roux
14. Sbu Nkosi
13. Jesse Kriel
12. Damian de Allende
11. Aphiwe Dyantyi
10. Handré Pollard
9. Embrose Papier
8 Duane Vermeulen
7. Pieter-Steph du Toit
6. Siya Kolisi (c)
5. Franco Mostert
4. RG Snyman
3. Frans Malherbe
2. Malcolm Marx
1. Steven Kitshoff
Replacements:
16. Bongi Mbonambi
17. Thomas du Toit
18. Vincent Koch
19. Eben Etzebeth
20. Francois Louw
21. Ivan van Zyl
22. Elton Jantjies
23. Cheslin Kolbe
