Francois Louw will start for South Africa as they take on Scotland at Murrayfield on Saturday.
The team has two changes from the one that beat Ireland last weekend, with Gurthrö Steenkamp and Juan de Jongh being included in the starting line-up at Murrayfield.
Steenkamp replaces CJ van der Linde at loosehead prop after the latter took over as late replacement from Tendai Mtawarira last weekend. De Jongh replaces Jaco Taute at outside centre. Both Van der Linde and Taute have been included on the bench.
Saturday's Test will be the 22nd between South Africa and Scotland since they first met in 1906. Of these, the Boks have won 16 and lost five, which includes the last time they played, in 2010. On that occasion, the Scots won, 21-17.
"Our focus has been on improving from our performance against Ireland last week," said Meyer. "We saw the match between Scotland and New Zealand and that the Scots scored three tries against the All Blacks – which is more than any other team has managed against them this year.
"It was their first Test back since their season started and they will not be an easy opponent on Saturday, but we've also brushed off some cobwebs in Dublin and have had a good week on the training field.
"We lost on our last visit to Edinburgh and realise Saturday will be a massive battle, but it's one we are looking forward to."
Springbok team to face Scotland:
15 Zane Kirchner
14 JP Pietersen
13 Juan de Jongh
12 Jean de Villiers (captain)
11 Francois Hougaard
10 Pat Lambie
9 Ruan Pienaar
8 Duane Vermeulen
7 Willem Alberts
6 Francois Louw
5 Juandré Kruger
4 Eben Etzebeth
3 Jannie du Plessis
2 Adriaan Strauss
1 Gurthrö Steenkamp
Replacements
16 Schalk Brits
17 Heinke van der Merwe
18 CJ van der Linde
19 Flip van der Merwe
20 Marcell Coetzee
21 Morné Steyn
22 Jaco Taute
23 Lwazi Mvovo
