Bath Rugby's new front row recruit, Paul James, will start for Wales this morning when they take on the ACT Brumbies (kick-off 10.30).
Lock Luke Charteris is the only player from Wales 1st Test defeat to Australia in Brisbane on Saturday to be retained in the starting line-up.
Head Coach Rob Howley has rung the changes as his side regroup after the 27-19 loss at the Suncorp Stadium in the first encounter of the three-Test series and called in Melbourne Rebels captain Gareth Delve from outside of his original 34-man squad.
Delve, who won the last of his 11 international caps in March 2010, became the first non-native to captain an Australian Super Rugby side last year and was already in the Southern Hemisphere when he got the call to replace the injured Toby Faletau late last night (Saturday).
Faletau will play no further part in the series after breaking a bone in his hand and is set to fly home for his injury to be reviewed in the next few days.
Meanwhile, the squad has also been buoyed by the arrival of Ospreys lock Ian Evans who joins Delve on the replacements bench, after arriving – also late last night - from his wedding in Greece. Charteris is partnered in the second row by 64-times capped Osprey Alun Wyn Jones, who also assumes the captaincy in place of the rested Sam Warburton.
In the front row James is partnered by his ex-regional team-mate Richard Hibbard at hooker and Scarlets prop Rhodri Jones, who made his Wales debut just a fortnight ago in the victory over the Barbarians. Scarlets flanker Josh Turnbull forms a back row partnership with his regional team-mate Aaron Shingler, who features at No8, and Ospreys openside specialist Justin Tipuric.
Two more players who made their debuts against the Baa-Baas, Blues wing Harry Robinson and Scarlets full-back Liam Williams, come into the backline with Ospreys centre Ashley Beck also making his second appearance in a Wales shirt after coming on for Scott Williams against the Wallabies on Saturday.
Another Regional partnership is reformed in the centre with the 16-times capped Andrew Bishop joining Beck - and James Hook features at fly-half to add his 64-caps worth of experience to the backline.
Dragons wing Aled Brew and Ospreys scrum-half Rhys Webb complete the starting line-up. On the bench, Delve and Evans are joined by Scarlets hooker Ken Owens and Saracens prop Rhys Gill as cover for the forwards. Rhys Priestland (Scarlets), Lloyd Williams and Alex Cuthbert (both Blues) provide the cover for the backs.
Wales team to face ACT Brumbies:
15. Liam Williams
14. Harry Robinson
13. Andrew Bishop
12. Ashley Beck
11. Aled Brew
10. James Hook
9. Rhys Webb
1. Paul James
2. Richard Hibbard
3. Rhodri Jones
4. Alun Wyn Jones (Captain)
5. Luke Charteris
6. Josh Turnbull
7. Justin Tipuric
8. Aaron Shingler
16. Ken Owens
17. Rhys Gill
18. Ian Evans
19. Gareth Delve
20. Lloyd Williams
21. Rhys Priestland
22. Alex Cuthbert