Following a dominant scrummaging display in the win over Gloucester at the Rec last Friday, Paul James has been selected to start for Wales against Scotland on Saturday.
Rec favourite James, who will win his 44th cap, replaces the injured Gethin Jenkins in the starting line-up.
"We have had two good, hard fought away victories but we know will have to be at our best again to come away from Murrayfield with the result," said Wales interim head coach Rob Howley.
"It's disappointing for Gethin to miss out but Paul has impressed and made an impact in each game he has played.
"We are bringing in a wealth of experience with Alun Wyn and Sam and they both performed well off the bench in Rome.
"Ryan has led the team to two wins and deserves to captain the side against Scotland.
"We have spoken a lot about momentum in this tournament and we go into the game with two wins under our belt but Scotland are in the same position and it's going to be a good challenge."
WALES: Leigh Halfpenny; Alex Cuthbert, Jonathan Davies, Jamie Roberts, George North, Dan Biggar, Mike Phillips; Paul James, Richard Hibbard, Adam Jones, Alun Wyn Jones, Ian Evans, Ryan Jones (capt), Sam Warburton, Toby Faletau.
REPLACEMENTS: Ken Owens, Scott Andrews, Craig Mitchell, Andrew Coombs, Justin Tipuric, Lloyd Williams, James Hook, Scott Williams.