Bath Rugby's George Ford and Jonathan Joseph will start with Anthony Watson among the replacements for England's RBS 6 Nations fixture against Scotland at Twickenham on Saturday, kick-off 16:00.
Ford continues at fly half, with Joseph returning to the matchday squad at outside centre. After missing the opening rounds through injury, Watson will be looking to make his impression off the bench.
Jack Nowell (Exeter Chiefs) is named on the right-wing and Ben Youngs (Leicester Tigers) starts at scrum-half as England look to maintain their unbeaten start to the Championship.
Billy Vunipola (Saracens) also makes his return to the England matchday 23 for the first time in this year’s Championship having returned from injury. They are joined by Danny Care (Harlequins) and Ben Te’o (Worcester Warriors) in the only other changes to the bench.
Saturday’s match will see 26-year old loose-head prop Joe Marler (Harlequins) win his 50th cap for England having made his debut against South Africa at Kings Park Stadium in Durban in 2012. To mark the milestone Marler will lead the team out of the tunnel for England’s 124th Calcutta Cup game.
“Our preparation for Scotland has been very good,” said England head coach Jones. “We had two excellent training runs in Oxford last week and followed that up this week.
“We’re focused on ourselves; we want to give our fans a really good performance. We’ve worked hard in this RBS 6 Nations and feel like a good performance is just around the corner.
“This is the 124th Calcutta Cup and I feel humbled and honoured to be part of such an historic rugby occasion, it’s the oldest international fixture and means a lot to both countries. We treasure the experience.
“I congratulate Joe Marler on his 50-cap milestone. I’ve coached a lot of good players and he is certainly one of the best. He is an honest and committed team man and a fine individual. To have him and Mako Vunipola available together to give us 80 minutes at loose-head is an enormous advantage.”
England team to face Scotland
15. Mike Brown (vice captain, Harlequins, 58 caps)
14. Jack Nowell (Exeter Chiefs, 21 caps)
13. Jonathan Joseph (Bath Rugby, 31 caps)
12. Owen Farrell (vice captain, Saracens, 50 caps)
11. Elliot Daly (Wasps, 11 caps)
10. George Ford (Bath Rugby, 33 caps)
9. Ben Youngs (Leicester Tigers, 68 caps)
1. Joe Marler (Harlequins, 49 caps)
2. Dylan Hartley (captain, Northampton Saints, 82 caps)
3. Dan Cole (Leicester Tigers, 72 caps)
4. Joe Launchbury (Wasps, 40 caps)
5. Courtney Lawes (Northampton Saints, 56 caps)
6. Maro Itoje (Saracens, 10 caps)
7. James Haskell (Wasps, 73 caps)
8. Nathan Hughes (Wasps, 6 caps)
16. Jamie George (Saracens, 15 caps)
17. Mako Vunipola (Saracens, 40 caps)
18. Kyle Sinckler (Harlequins, 6 caps)
19. Tom Wood (Northampton Saints, 48 caps)
20. Billy Vunipola (vice captain, Saracens 32 caps)
21. Danny Care (Harlequins, 69 caps)
22. Ben Te’o (Worcester Warriors, 6 caps)
23. Anthony Watson (Bath Rugby, 24 caps)