George Ford and Anthony Watson will start England’s final Pool A game in the Rugby World Cup against Uruguay on Saturday, kick-off 20.00.
They are joined in the squad by Bath Rugby teammates Jonathan Joseph and David Wilson, who are both named on the bench.
England Head Coach Stuart Lancaster said: “Brad Barritt (arm) and Courtney Lawes (knee) are not available this weekend and Ben Morgan (dead leg) and Ben Youngs (ankle) will not be able to train fully until Thursday.
“This is an opportunity for us to finish the tournament with a strong performance against Uruguay and a chance for the likes of young players such as Jack Nowell and Henry Slade to play in a World Cup.
“We owe it to ourselves and the supporters who have been brilliant throughout. This is an important game for rugby in the north of England and we want to give those people who have been looking forward to this game something to cheer about.”
England team to face Uruguay
15 Alex Goode
14 Anthony Watson
13 Henry Slade
12 Owen Farrell
11 Jack Nowell
10 George Ford
9 Danny Care
1 Mako Vunipola
2 Tom Youngs
3 Dan Cole
4 Joe Launchbury
5 Geoff Parling
6 James Haskell
7 Chris Robshaw ( c )
8 Nick Easter
Replacements
16 Jamie George
17 Joe Marler
18 David Wilson
19 George Kruis
20 Tom Wood
21 Richard Wigglesworth
22 Jonathan Joseph
23 Mike Brown