George Ford and Jonathan Joseph have both been named in England's match squad for the Test against France on Saturday, kick-off 20.00.
The Bath Rugby pair are two of 14 changes to the starting-line up, with try-scorer Jonny May retained from the team that beat France 19-14 in the QBE International at Twickenham Stadium last Saturday. Dave Attwood and David Wilson both retain their places on the bench.
Chris Robshaw forms the back row alongside James Haskell and Billy Vunipola that started the final RBS 6 Nations against France, with 12 of that XV lining up in Paris.
Joe Launchbury (Wasps) plays his first international in 12 months after returning from injury while there is also a place in the matchday 23 for the first time for Saracens hooker Jamie George.
England Head Coach Stuart Lancaster said: "Having reviewed last Saturday there were a lot of things we were pleased with considering it was the first game. There is now an opportunity for those not involved or who didn't get much opportunity from the bench to put a marker down and build on that performance.
"France were very good last weekend and will be even stronger at home and this will be a big test but these guys have been working hard for the opportunity and are desperate to go out and perform. I'm delighted for Jamie George who hopefully gets his first cap and also Joe Launchbury, who has worked tirelessly and patiently to get back to fitness.
"It is a big couple of weeks ahead for all the 39-man squad with the game this weekend and some competitive training sessions to come this week and next as we look to narrow down the squad ahead of the World Cup."
England team to play France
15 Mike Brown
14 Jack Nowell
13 Jonathan Joseph
12 Luther Burrell
11 Jonny May
10 George Ford
9 Ben Youngs
1 Joe Marler
2 Tom Youngs
3 Dan Cole
4 Joe Launchbury
5 Courtney Lawes
6 James Haskell
7 Chris Robshaw ( c)
8 Billy Vunipola
16 Jamie George
17 Mako Vunipola
18 David Wilson
19 Dave Attwood
20 Nick Easter
21 Danny Care
22 Danny Cipriani
23 Billy Twelvetrees
August 22nd, Stade de France, France v England, 21.00 (local time)
September 5th, QBE International, Twickenham Stadium, England v Ireland, 14.30
September 18th, RWC 2015, Twickenham Stadium, England v Fiji, 20.00
September 26th, RWC 2015, Twickenham Stadium, England v Wales, 20.00
October 3rd, RWC 2015, Twickenham Stadium, England v Australia, 20.00
October 10th, RWC 2015, Manchester City Stadium, England v Uruguay, 20.00