Bath Rugby's Taulupe Faletau will start at number eight for Wales against Australia at Principality Stadium on Saturday, kick-off 17:15.
Alun Wyn Jones captains the side and is one of seven returning British & Irish Lions to line-up in the starting XV for the clash against the Wallabies, alongside Ken Owens, Taulupe Faletau, Dan Biggar, Jonathan Davies, Liam Williams and Leigh Halfpenny.
Three players will make their home debut at Principality Stadium, Owen Williams and Steff Evans in the backline and flanker Josh Navidi.
Captain Jones will pack down alongside Jake Ball in the second-row, behind a front-row of Rob Evans, Owens and Tomas Francis.
Aaron Shingler and Navidi - who both featured in the two Test victories over Tonga and Samoa in the summer - start in the back-row alongside Faletau.
Gareth Davies partners Biggar at halfback with Williams named at inside centre alongside Davies.
Evans, who scored two tries for Wales in his last outing against Samoa, is part of a back-three alongside Williams and full-back Halfpenny.
Three uncapped players have been named on the bench: Dragons prop Leon Brown and Ospreys duo Sam Cross and Owen Watkin.
Kristian Dacey and Nicky Smith make up the front-row replacements alongside Brown with Cory Hill completing the forward contingent. Aled Davies and Hallam Amos join Watkin as the backline replacements.
"We are really looking forward to Saturday and getting the Under Armour Series underway," said Wales Head Coach Warren Gatland.
"I'm delighted for Steff Evans, Owen Williams and Josh Navidi that they get their first start at home, the atmosphere will be fantastic and it's a great opportunity for them.
"It's going to be a tough first up game, we know that and we need to be up and running. We have a squad that's packed with talent and is on form and we are excited to see what they can do."
Wales team to face Australia
15. Leigh Halfpenny (Scarlets) (71 Caps); 14. Liam Williams (Saracens) (43 Caps, 13. Jonathan Davies (Scarlets) (64 Caps), 12. Owen Williams (Gloucester) (1 Cap), 11. Steff Evans (Scarlets) (2 Caps); 10. Dan Biggar (Ospreys) (56 Caps), 9. Gareth Davies (Scarlets) (26 Caps); 1. Rob Evans (Scarlets) (17 Caps), 2. Ken Owens (Scarlets) (50 Caps), 3. Tomas Francis (Exeter Chiefs) (23 Caps), 4. Jake Ball (Scarlets) (26 Caps), 5. Alun Wyn Jones (CAPT) (Ospreys) (110 Caps), 6. Aaron Shingler (Scarlets) (10 Caps), 7. Josh Navidi (Cardiff Blues) (3 Caps), 8. Taulupe Faletau (Bath Rugby) (66 Caps)
16. Kristian Dacey (Cardiff Blues) (4 Caps), 17. Nicky Smith (Ospreys) (14 Caps), 18. Leon Brown (Dragons), (*UNCAPPED), 19. Cory Hill (Dragons) (6 Caps), 20. Sam Cross (Ospreys) (*UNCAPPED), 21. Aled Davies (Scarlets) (2 Caps), 22. Owen Watkin (Ospreys) (*UNCAPPED), 23. Hallam Amos (Dragons) (11 Caps)