Kyle Eastmond has been named in the England starting XV when they play a Sudamerica XV in Montevideo, Uruguay this Sunday, kick-off 19.30 BST.
After coming off the bench against the Barbarians and capping a good performance with a try, Eastmond is one of seven players making their first senior start in this non cap encounter.
Kearnan Myall (unattached), Henry Thomas (Sale Sharks) and Billy Vunipola (London Wasps) also all came off the bench in England's 40-12 win over the Barbarians and Jonny May (Gloucester Rugby) has been brought on to the wing. Replacement hooker Rob Buchanan (Harlequins) will also make his first appearance at this level should he be used from the bench.
The side will be led by Northampton Saints flanker Tom Wood, who will be joined by his team mates Luther Burrell, Ben Foden, Courtney Lawes and Stephen Myler in the starting line-up, eight days after playing in the Aviva Premiership final.
Bath forward Dave Attwood drops to the bench for the match along with Jonathan Joseph, whilst hooker Rob Webber and front rower David Wilson, are rested for the encounter.
Head Coach Stuart Lancaster said: "We have made a lot of changes from the Barbarians game as this tour is about giving players opportunities to show their talent. However, the objective is to build on that performance to keep our game moving forward. The players understand this responsibility and are looking forward to the challenge.
"Everyone involved will need to hit the ground running in Uruguay because we expect the Sudamerica side to play with a lot of skill and physicality in front of a passionate home crowd. It is England's first ever match on Uruguayan soil and should be a great occasion for all concerned."
England team to play Sudamerica XV
15 Ben Foden (Northampton Saints)
14 Jonny May (Gloucester Rugby)
13 Luther Burrell (Northampton Saints)
12 Kyle Eastmond (Bath Rugby)
11 David Strettle (Saracens)
10 Stephen Myler (Northampton Saints)
9 Richard Wigglesworth (Saracens)
1 Joe Marler (Harlequins)
2 David Paice (London Irish)
3 Henry Thomas (Sale Sharks)
4 Courtney Lawes (Northampton Saints)
5 Kearnan Myall (Unattached)
6 Tom Wood (Northampton Saints, captain)
7 Tom Johnson (Exeter Chiefs)
8 Billy Vunipola (London Wasps)
16 Rob Buchanan (Harlequins)
17 Alex Corbisiero (London Irish)
18 Paul Doran Jones (Northampton Saints)
19 Dave Attwood (Bath Rugby)
20 Matt Kvesic (Worcester Warriors)
21 Lee Dickson (Northampton Saints)
22 Freddie Burns (Gloucester Rugby)
23 Jonathan Joseph (London Irish)