The Bath Rugby backs trio of George Ford, Jonathan Joseph and Anthony Watson once against start for England in the RBS 6 Nations as they meet Italy in Rome (k.o. 14.00).
Ollie Devoto will also travel with the squad as they seek two wins from two in the competition.
Eddie Jones has also named second row Courtney Lawes, tight-head prop Mako Vunipola and scrum half Ben Youngs in his starting side to face Italy at the Stadio Olimpico on Sunday (kick-off 2pm, live on ITV).
Saracens’ Vunipola, who made a big impact off the bench in last week’s Calcutta Cup victory over Scotland, is selected in front of Harlequins’ Joe Marler as England go head-to-head with an Italian side who narrowly lost to France in Paris last weekend.
Courtney Lawes and Ben Youngs replace Joe Launchbury and Danny Care who both move to the bench. Elsewhere Saracens’ second row Maro Itoje is included as a replacement for the first time joining fellow debutant Paul Hill (Northampton Saints) who was unused last weekend.
Explaining the selection, head coach Eddie Jones said the three new names in his starting 15 had impressed off the bench at Murrayfield and suited the way he wants the side to play against Italy.
“We’ve made a few changes to the line up for Italy. I believe this is the strongest 23 to go to Rome and get the performance and result we want.” Jones said.
“We are confident we can go to Rome and win, but we’re in no doubt of the challenge we face. Italy took France very close last weekend in Paris so they’ll be fired up."
England match-day 23 to face Italy
15. Mike Brown (vice captain, Harlequins, 44 caps)
14. Anthony Watson (Bath Rugby, 16 caps)
13. Jonathan Joseph (Bath Rugby, 17 caps)
12. Owen Farrell (vice captain, Saracens, 36 caps)
11. Jack Nowell (Exeter Chiefs, 11 caps)
10. George Ford (Bath Rugby, 18 caps)
9. Ben Youngs (Leicester Tigers, 53 caps)
1. Mako Vunipola (Saracens, 28 caps)
2. Dylan Hartley (captain, Northampton Saints, 67 caps)
3. Dan Cole (Leicester Tigers, 57 caps)
4. Courtney Lawes (Northampton Saints, 43 caps)
5. George Kruis (Saracens, 11 caps)
6. Chris Robshaw (Harlequins, 44 caps)
7. James Haskell (Wasps, 63 caps)
8. Billy Vunipola (vice captain, Saracens, 22 caps)
16. Jamie George (Saracens, 4 caps)
17. Joe Marler (Harlequins, 38 caps)
18. Paul Hill (Northampton Saints, uncapped)
19. Joe Launchbury (Wasps, 29 caps)
20. Maro Itoje (Saracens, uncapped)
21. Jack Clifford (Harlequins, 1 cap)
22. Danny Care (Harlequins, 54 caps)
23. Alex Goode (Saracens, 19 caps)