The Bath Rugby quartet of Dave Attwood, George Ford, Jonathan Joseph and Anthony Watson start their fourth consecutive Six Nations match for England on Saturday in the Calcutta Cup clash at Twickenham (5pm, live on BBC One).
England are looking to fight their way back into Six Nations contention after a bright start to the tournament was put on hold in Dublin.
Mike Brown and Courtney Lawes are the only changes to the XV which started against Ireland at the Aviva Stadium. Leicester Tigers second row Geoff Parling and Northampton Saints back row Tom Wood also come back into the match day squad while Kieran Brookes (Newcastle Falcons) makes a return from a hip injury.
England Head Coach Stuart Lancaster said: "There's always a lot of competition for places and having experienced players like Courtney, Tom and Geoff available after playing well for their clubs in the last few weeks adds to our options.
"It's been an intense two weeks of training as everyone wants to be on that field on Saturday and we have had to make some tough selection calls.
"Coming back to Twickenham will be huge for us and we are determined to put in a performance against a strong and motivated Scotland team."
England Rugby team to face Scotland
15. Mike Brown (Harlequins, 35 caps)
14. Anthony Watson (Bath Rugby, 7 caps)
13. Jonathan Joseph (Bath Rugby, 9 caps)
12. Luther Burrell (Northampton Saints, 10 caps)
11. Jack Nowell (Exeter Chiefs, 6 caps)
10. George Ford (Bath Rugby, 9 caps)
9. Ben Youngs (Leicester Tigers, 45 caps)
1. Joe Marler (Harlequins, 29 caps)
2. Dylan Hartley (Northampton Saints, 64 caps)
3. Dan Cole (Leicester Tigers, 48 caps)
4. Dave Attwood (Bath Rugby, 19 caps)
5. Courtney Lawes (Northampton Saints, 36 caps)
6. James Haskell (Wasps, 56 caps)
7. Chris Robshaw (captain, Harlequins, 35 caps)
8. Billy Vunipola (Saracens, 15 caps)
16. Tom Youngs (Leicester Tigers, 20 caps)
17. Mako Vunipola (Saracens, 18 caps)
18. Kieran Brookes (Newcastle Falcons, 8 caps)
19. Geoff Parling (Leicester Tigers, 21 caps)
20. Tom Wood (Northampton Saints, 34 caps)
21. Richard Wigglesworth (Saracens, 19 caps)
22. Danny Cipriani (Sale Sharks, 10 caps)
23. Billy Twelvetrees (Gloucester Rugby, 19 caps)