Bath flyer Tom Biggs will start against the O2 Ireland Wolfhounds on Friday night, while Kyle Eastmond will be on the bench.
Former rugby league star Eastmond has impressed the Rec faithful since kick-starting his rugby union career this season, and he is one of nine debutants in a new-look Saxons outfit.
Elliot Daly, Joel Tomkins, George Ford, George Kruis and Will Fraser all start for the first time, with our man Eastmond being joined on the bench by Rob Buchanan, Shaun Knight, and George Lowe.
Head Coach and Bath legend Jon Callard said: "This is a dynamic young side with an average age of less than 24 and the players have a chance to show that they can play a major part of the future of England Rugby over the coming years. The blend of forward power and pace in the back line makes it an exciting one to be involved with.
"We're facing an experienced Irish side in this opening game and the challenge is to step up and deliver a high quality performance in front of a passionate crowd in Galway."
After facing the Wolfhounds away from home the Saxons return to England to do battle with Scotland A at Newcastle on Friday, February 1st (8pm).
15 Elliot Daly (London Wasps)
14 Christian Wade (London Wasps)
13 Joel Tomkins (Saracens)
12 Jordan Turner-Hall (Harlequins)
11 Tom Biggs (Bath Rugby)
10 George Ford (Leicester Tigers)
9 Richard Wigglesworth (Saracens)
1 Nick Wood (Gloucester Rugby)
2 Joe Gray (Harlequins)
3 Paul Doran-Jones (Northampton Saints)
4 Graham Kitchener (Leicester Tigers)
5 George Robson (Harlequins)
6 George Kruis (Saracens)
7 Will Fraser (Saracens)
8 Jordan Crane (Leicester Tigers, captain)
16 Rob Buchanan (Harlequins)
17 Matt Mullan (Worcester Warriors)
18 Shaun Knight (Gloucester Rugby)
19 Ed Slater (Leicester Tigers)
20 Jamie Gibson (London Irish)
21 Joe Simpson (London Wasps)
22 George Lowe (Harlequins)
23 Kyle Eastmond (Bath Rugby)