Bath Rugby's Dave Attwood has been included in England's matchday 23 to face France on Saturday in Paris, kick-off 17.00.
Attwood will look to add to his five caps should he be called on from the bench.
New caps Luther Burrell and Jack Nowell come into the backline, alongside Gloucester's Jonny May on the wing and Danny Care at scrum-half.
While four of the backline are changed from the team that started against New Zealand, the pack remains unchanged.
England Head Coach Stuart Lancaster said: "We can't wait for Saturday. We've had a good two weeks and all the players have pushed hard for selection.
"Congratulations to Jack and Luther who deserve their chance, as does Jonny May starting his first RBS 6 Nations game. It's also great to see Brad Barritt back with his experience and leadership in the 23, while Alex Goode will give us good cover at 15 and 10.
"We felt the pack went well in the autumn and it's right to leave it unchanged but we have some quality players, including two British Lions in Tom and Mako, to come on."
Bath duo George Ford and Anthony Watson are included in the squad travelling to France as cover, along with prop Matt Mullan..
England team to face France
15 Mike Brown (Harlequins, 21 caps)
14 Jack Nowell (Exeter Chiefs, uncapped)
13 Luther Burrell (Northampton Saints, uncapped)
12 Billy Twelvetrees (Gloucester Rugby, 8 caps)
11 Jonny May (Gloucester Rugby, 1 cap)
10 Owen Farrell (Saracens, 19 caps)
9 Danny Care (Harlequins, 42 caps)
1 Joe Marler (Harlequins, 15 caps)
2 Dylan Hartley (Northampton Saints, 50 caps)
3 Dan Cole (Leicester Tigers, 43 caps)
4 Joe Launchbury (London Wasps, 14 caps)
5 Courtney Lawes (Northampton Saints, 25 caps)
6 Tom Wood (Northampton Saints, 23 caps)
7 Chris Robshaw (Harlequins, capt, 20 caps)
8 Billy Vunipola (Saracens, 5 caps)
16 Tom Youngs (Leicester Tigers, 12 caps)
17 Mako Vunipola (Saracens, 10 caps)
18 Henry Thomas (Sale Sharks, 2 caps)
19 Dave Attwood (Bath Rugby, 5 caps)
20 Ben Morgan (Gloucester Rugby, 15 caps)
21 Lee Dickson (Northampton Saints, 12 caps)
22 Brad Barritt (Saracens, 16 caps)
23 Alex Goode (Saracens, 13 caps)