Bath Rugby's loosehead Paul James could come up against some familiar faces on Sunday having kept his place on the Wales bench to face England (kick-off 15.00).
Warren Gatland has made two changes to his squad, as British and Irish Lions duo Jonathan Davies (Scarlets) and Alun Wyn Jones (Ospreys) return to the starting XV.
"It's great to have both Jon and Alun Wyn back and available and they come into a very experienced side,” said Gatland.
"Jon came through the match well at the weekend and he is ready to go.
"We were happy with the response and performance against France but we know we will have to raise it another level on Sunday.
"We are really looking forward to going up to Twickenham, England have performed well so far and it's set up to be a great game with all to play for.”
Wales squad to play England:
Leigh Halfpenny (Cardiff Blues), Alex Cuthbert (Cardiff Blues), Jonathan Davies (Scarlets), Jamie Roberts (Racing Metro), George North (Northampton Saints), Rhys Priestland (Scarlets), Rhys Webb (Ospreys), Gethin Jenkins (Cardiff Blues), Richard Hibbard (Ospreys), Adam Jones (Ospreys), Luke Charteris (Perpignan), Alun Wyn Jones (Ospreys), Dan Lydiate (Racing Metro), Sam Warburton (CAPT – Cardiff Blues), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Paul James (Bath Rugby), Rhodri Jones (Scarlets), Jake Ball (Scarlets), Justin Tipuric (Ospreys), Mike Phillips (Racing Metro), Dan Biggar (Ospreys), Liam Williams (Scarlets).