Bath Rugby's Paul James, Francois Louw and Tom Heathcote will all be in international action this Saturday.
James has retained his starting spot in the front row as Wales look to secure their first victory of the Autumn series when they host the All Blacks at the Millennium Stadium.
Wales' selectors have made five changes in all, with Sam Warburton returning the lead the side, Luke Charteris coming into the second row and Matthew Rees replacing Richard Hibbard at hooker.
Rhys Priestland takes over from Dan Biggar at fly-half, and Jonathan Davies returns from injury to link up with Jamie Roberts in the centres.
Wales: Leigh Halfpenny; Alex Cuthbert, Jonathan Davies, Jamie Roberts, George North; Rhys Priestland, Mike Phillips; Paul James, Matthew Rees, Aaron Jarvis, Bradley Davies, Luke Charteris, Ryan Jones, Sam Warburton (captain), Toby Faletau
Replacements:Ken Owens, Gethin Jenkins, Scott Andrews, Aaron Shingler, Justin Tipuric, Tavis Knoyle, James Hook, Scott Williams
Louw continues to impress for the Springboks, and also retains his place following his Man of the Match performance against Scotland last week.
Springbok coach Heyneke Meyer has named an unchanged starting line-up for the final Test of the season, taking on England at Twickenham.
He retained the team that defeated Scotland, 21-10, last weekend with JP Pietersen and Gurthrö Steenkamp, cleared for selection after treatment of niggling injuries.
The only changes are on the bench, where Pat Cilliers comes in for the injured CJ van der Linde and Elton Jantjies replaces Morné Steyn.
South Africa: Zane Kirchner, JP Pietersen, Juan de Jongh, Jean de Villiers (captain), Francois Hougaard, Pat Lambie, Ruan Pienaar; Gurthrö Steenkamp, Adriaan Strauss, Jannie du Plessis, Eben Etzebeth, Juandré Kruger, Francois Louw, Willem Alberts, Duane Vermeulen.
Replacements: Schalk Brits, Heinke van der Merwe, Pat Cilliers, Flip van der Merwe, Marcell Coetzee, Elton Jantjies, Jaco Taute, Lwazi Mvovo
Heathcote has been named on the bench having joined up with the Scotland squad on Monday.
Andy Robinson has made five changes in all to his side that started against South Africa, with a further four on the bench.
The changes in the team see Max Evans return at outside centre, Henry Pyrgos, who scored Scotland's try against South Africa last weekend, is handed the starting jersey at scrum-half for the first time instead of Mike Blair, while Scott Lawson will begin his first international since August 2011 at hooker rather than Ross Ford.
At lock, Alastair Kellock gets the nod over Jim Hamilton to win his 47th cap, while in the back-row Alasdair Strokosch is restored from the calf injury that prevented his involvement against the Springboks.
On the bench the uncapped Edinburgh Rugby lock Grant Gilchrist – a recipient of the 2011 John MacPhail Scholarship – is nominated in a Scotland match-day 23 for the first time, as is Heathcote.
At the other end of the experience scale, substitute scrum-half Rory Lawson is back on Scotland duty for the first time since the 2011 Rugby World Cup match against Argentina.
Scotland: Stuart Hogg, Sean Lamont, Max Evans, Matt Scott, Tim Visser, Greig Laidlaw, Henry Pyrgos; Ryan Grant, Scott Lawson, Euan Murray, Richie Gray, Alastair Kellock, Alasdair Strokosch, Kelly Brown (captain), David Denton
Substitutes: Dougie Hall, Kyle Traynor, Geoff Cross, Grant Gilchrist, John Barclay, Rory Lawson, Tom Heathcote, Nick De Luca