Bath Rugby's Ruaridh McConnochie and Anthony Watson have both been selected to start in Eddie Jones' England side to face Italy, with Charlie Ewels and Joe Cokanasiga named on the bench.
England face Italy in the final Quilter International on Friday at St James’ Park in Newcastle (kick-off 19:45 live on Sky Sports).
The squad set off to Japan for the Rugby World Cup on Sunday.
A mix and match selection strategy sees Joe Marchant named at outside centre with Piers Francis at inside centre. Owen Farrell, who captains the team, starts at fly half while debutant Ruaridh McConnochie is named on the right wing with Anthony Watson at fullback.
Dan Cole starts alongside Jamie George and Joe Marler in the front row with Joe Launchbury and Courtney Lawes named as the lock pairing. Mark Wilson will start at openside flanker with Tom Curry and Billy Vunipola making up the rest of the back row.
Jones said: “We are delighted to be playing against Italy, one of our traditional Six Nations rivals and the game for us is another important step to develop our game fitness and game strategy. We have gone with a mix and match selection policy to develop our adaptability and the team’s ability to cope with any situation.
“We have had a solid training week in Treviso with hot conditions so we are looking forward to testing ourselves against Italy on Friday night. Then we hop on the plane and are ready to go to Japan.”
England starting XV v Italy
15 Anthony Watson (Bath Rugby, 35 caps)
14 Ruaridh McConnochie (Bath Rugby, uncapped)
13 Joe Marchant (Harlequins, 2 caps)
12 Piers Francis (Northampton Saints, 7 caps)
11 Jonny May (Leicester Tigers, 46 caps)
10 Owen Farrell (Saracens, 72 caps) C
9 Ben Youngs (Leicester Tigers, 88 caps)
1 Joe Marler (Harlequins, 61 caps)
2 Jamie George (Saracens, 39 caps)
3 Dan Cole (Leicester Tigers, 88 caps)
4 Joe Launchbury (Wasps, 60 caps)
5 Courtney Lawes (Northampton Saints, 74 caps)
6 Tom Curry (Sale Sharks, 12 caps)
7 Mark Wilson (Newcastle Falcons/Sale Sharks, 14 caps)
8 Billy Vunipola (Saracens, 44 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 14 caps)
17 Ellis Genge (Leicester Tigers, 11 caps )
18 Kyle Sinckler (Harlequins, 24 caps)
19 Charlie Ewels (Bath Rugby, 11 caps)
20 Matt Kvesic (Exeter Chiefs, 3 caps)
21 Willi Heinz (Gloucester Rugby, 3 caps)
22 George Ford (Leicester Tigers, 58 caps)
23 Joe Cokanasiga (Bath Rugby, 7 caps)