Gregor Townsend makes four changes to his team, selecting the Bath Rugby at centre to face Italy at Murrayfield.
Cameron Redpath will add to his four Scotland caps as he comes off the bench this weekend in the final round of the Six Nations.
The centre will feature for the first time in this campaign since being named in Townsend's Six Nations training squad.
Redpath's last international appearance came off the bench against Argentina in the 2022 Autumn Nations Series where the centre crossed the whitewash in his first try for his country.
Scotland: 15 Ollie Smith, 14 Kyle Steyn, 13 Huw Jones, 12 Sione Tuipolotu (vc), 11 Duhan van der Merwe, 10 Blair Kinghorn, 9 Ben White; 1 Pierre Schoeman, 2 George Turner, 3 Zander Fagerson, 4 Sam Skinner, 5 Johnny Gray, 6 Jamie Ritchie (c), 7 Hamish Watson, 8 Jack Dempsey.
Replacements: 16 Ewan Ashman, 17 Rory Sutherland, 18 W P Nel, 19 Scott Cummings, 20 Matt Fagerson, 21 Ali Price, 22 Ben Healy, 23 Cameron Redpath
Italy: 15 Tommaso Allan, 14 Pierre Bruno, 13 Juan Ignacio Brex, 12 Tommaso Menoncello, 11 Simone Gesi, 10 Paolo Garbisi, 9 Alessandro Fusco, 8 Lorenzo Cannone; 1 Danilo Fischetti, 2 Giacomo Nicotera, 3 Marco Riccioni, 4 Edoardo Iachizzi, 5 Federico Ruzza, 6 Sebastian Negri, 7 Michele Lamaro (c)
Replacements: 16 Marco Manfredi, 17 Federico Zani, 18 Pietro Ceccarelli, 19 Niccolo Cannone, 20 Giovanni Pettinelli, 21 Manuel Zuliani, 22 Alessandro Garbisi, 23 Luca Morisi
Watch Scotland v Italy on BBC One, Saturday 18 March, kick-off 12:30.