Ollie Lawrence will take the inside centre jersey when England face France on Saturday.
Since being named in Steve Borthwick's Six Nations squad, the 23-year-old has earned himself a Player of the Match accolade after a shining performance against Italy.
He also crossed the white wash in England's last outing during their victory over Wales at the Principality Stadium.
Lining up in the centre, Lawrence will be paired with Henry Slade at 13, with Anthony Watson, Max Malins and Freddie Steward completing the back line.
Of his team's selection, Steve Borthwick said: "We look forward to welcoming a strong France team to Twickenham this weekend in what will undoubtedly be another exciting encounter in this year’s Six Nations competition."
"Over the last three years France have built a formidable side and with just three games behind us, this England team has an excellent opportunity to test itself against one of the very best teams in the world, as we progress and build on the foundations we have put in place in the short time we have been together.
"The players selected to face our visitors are again a reflection of what I see to be the right balance of personnel for the challenge we face in this game. Marcus Smith starts at fly half and Dave Ribbans returns to the match day 23.
"Congratulations to Ellis Genge who will captain the side for the first time. Ellis will lead from the front with the sort of dedication and spirit that now rightly typifies this England team.
"I know that a sold-out Twickenham will be in full voice, and that our magnificent supporters will make Saturday a very special occasion with a brilliant atmosphere.”
The game fixture kicks off at 16:45 on Saturday 11 March at Twickenham Stadium.
u20 six nations comes to the rec
We're welcoming England U20 to The Rec as they take on France U20 this Friday night.
Our very own Sam Harris will be taking on the role of full back in England U20's unbeaten run in the competition.
Tickets start at just £15 per adult. Don't miss what looks set to be an epic fixture!